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KMID : 1141020180180010047
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Journal of Applied Oriental Medicine
2018 Volume.18 No. 1 p.47 ~ p.56
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Anti-dementia effect of Pseudostellaria heterophylla on scopolamine-induced memory impairment
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Lee Soo-Hwa
Jung Ji-Wook
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Abstract
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Pseudostellaria heterophylla is a traditional medical plant used 3,000 years. It contrains polysaccharides, ginseng sapoinins, flavonoids, cyclic peptides, amino acids, and trace element. However, this is the incomplete of research on the Pseudostellaria heterophylla. In this study, we have investigated the anti-dementia effects of Pseudostellaria heterophylla on hot water extract on scopolamine-induced memory impairment in ICR male mice. To determine the effect of Pseudostellaria heterophylla on the cognitive dysfunction, we have injected scopolamine (1 ㎎/㎏, i.p.) in ICR male mice and conducted Y-maze, passive avoidance tests. Scopolamineinduced an array of behavior changes of memory impairments were recovered by oral administration of Pseudostellaria heterophylla (100, 200 or 400 ㎎/㎏). To further verify the acethylcholinestrase activity effect of Pseudostellaria heterophylla on the scopolmaine-induced memory impairment, Donepezil (positive control) on expression of IC50 was 0.007 ㎕/㎖, and then Pseudostellaria heterophylla on expression of IC50 was 0.02 ㎕/㎖. Pseudostellaria heterophylla (Miq.) Pax. et Hoffm treatment down-regulated the acetylcholine esterase activity enhanced scopolamine-induced memory impairment. These results suggest that enhanced may have preventive and/or therapeutic potentials in the management of dementia.
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KEYWORD
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Pseudostellaria heterophyll, memory, amnesia
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